PSA opens on Morgan Freeman discussing the importance of breakthrough approaches in treating cancer. He narrates throughout as we go through different science and patient related shots. This leads into a shot of a cancer survivor, followed by a scientist doing research, and back to Morgan Freeman. This goes into an animation that leads to the title of the PSA: Be The Breakthrough. It’s followed by the Call To Action: Talk to your doctor about screenings, clinical trials, and especially prevention. PSA ends on a card reading #cancerbreakthrough, with the Stand Up To Cancer, Genentech and The C Word logos.