The film is a music video set to an original song - "It's Good to Have a Change of Heart".

It explains the science of heart failure through the story of Dan, a drummer in a band called "The H Beats". Heart failure is starting to affect Dan's performance. Seeing this, a compassionate friend takes him on a journey to learn about the condition and how ENTRESTO can help.

By the end, Dan has had a change of heart that restores his beat and his joy in living life.

Change is at the heart of our story and our song. The chorus line, "It's good to have a change of heart", is repeated throughout.

That theme of change is reflected in our animation. Every time the chorus hits, the animation style changes. We go from a 2-D style in the verses to a variety of 3-D styles in the choruses. The first chorus uses a paper texture for the characters and backgrounds. The second uses a wood texture. The third chorus is CGI. And the final chorus uses characters and backgrounds that look like clay.

It's a constantly changing animation approach that's appropriate for a brand that's changing heart failure treatment.

Branded pharma content in the US is strictly regulated as is content on Youtube. Per regulations, our two minute method of action video is followed by more than 3 minutes of scrolling safety information.

Our target is patients who've been diagnosed with heart failure and those who will be (1 in 5 people will develop heart failure in their lifetime). Heart failure is a serious condition that's often misunderstood. Education is sorely needed.